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    MV Cheng & Associates in the Press – MV Cheng & Associates

    Ann Clin Lab Res. Background: Children with steroid resistant nephrotic syndrome SRNS are at a greater risk of metabolic bone disease due to biochemical derangements by corticosteroids and immunosuppressant therapy. Method: A cross-sectional case control study was performed to investigate the calcium-vitamin D status in 50 patients of SRNS and 40 healthy controls. Conclusion: There is a clear diminution of serum 25 OH D in patients with SRNS which reverts rapidly to normal after cessation of proteinuria which may associate with severe nephrotoxicity. Prophylactic therapy with vitamin D should be routinely advocated in these patients.
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